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Archive for the ‘Clinical Research’ Category

Factors Involved in the Development of Osteoarthritis After Anterior Cruciate Ligament Surgery

Thursday, July 1st, 2010

Abstract

Background The incidence of osteoarthritis after anterior cruciate ligament reconstruction is disturbingly high, with reports of nearly 50% of patients developing mild to moderate osteoarthritis 6 years after surgery. Few studies have assessed the factors involved in the development of osteoarthritis.

Hypothesis The following 10 factors will be found to be predictive of osteoarthritis: meniscectomy, chondral damage, patellar tendon grafting, age at surgery, time delay between injury and surgery, type and intensity of postsurgery sport, quadriceps strength, hamstring strength, quadriceps-to-hamstring strength ratio, and residual joint laxity.

Study Design Cohort study (prognosis); Level of evidence, 1.

Methods Fifty-six subjects with anterior cruciate ligament reconstruction were followed for 6 years after surgery. Assessment included KT-1000 arthrometer testing, isokinetic strength testing, a return-to-sport questionnaire, and a radiograph assessment. A discriminant analysis was performed to assess which of the 10 factors could discriminate between those patients who developed tibiofemoral and patellofemoral osteoarthritis and those who did not.

Results Five factors were found to be predictive of tibiofemoral osteoarthritis. Meniscectomy (r = .72) and chondral damage (r = .41) were the strongest discriminators, followed by patellar tendon grafting (r = .37) (χ2 [7, n = 56] = 25.48; P = .001). Weak quadriceps (r = .39) and low quadriceps-to-hamstring strength ratios (r = .6) were very close discriminators (χ2 [8, n = 42] = 15.02; P = .059). For patellofemoral osteoarthritis, meniscectomy (r = .45), chondral damage (r = .75), and age at surgery (r = .65) were predictors or close predictors (χ2 [7, n = 54] = 13.30; P = .065).

Conclusion As not all 10 factors studied were predictive of osteoarthritis, the hypothesis was only partially proven. Preventing further meniscal and chondral damage in patients with anterior cruciate ligament deficiency is critical. Grafting using the hamstring tendons and restoration of quadriceps-to-hamstring strength balance are associated with less osteoarthritis.

  1. Susan L. Keays, PT, PhD*,
  2. Peter A. Newcombe, PhD§,
  3. Joanne E. Bullock-Saxton, PT, PhD||,
  4. Margaret I. Bullock, PT, PhD, AM, FTSE|| and
  5. Anthony C. Keays, MD

Intrinsic Risk Factors for Hamstring Injuries Among Male Soccer Players: A Prospective Cohort Study

Thursday, June 10th, 2010
  1. Anders Hauge Engebretsen, MD
  2. Grethe Myklebust, PT, PhD
  3. Ingar Holme, PhD
  4. Lars Engebretsen, MD, PhD
  5. Roald Bahr, MD, PhD

Am J Sports Med June 2010 38:1147-1153; doi:10.1177/036354650935838

Abstract

Background: Strain injuries of the posterior thigh are common in soccer. It seems that previous injury and age are important risk factors, but the literature is limited. This study was conducted to see if we could identify intrinsic risk factors for hamstring injuries among male soccer players.

Hypothesis: We hypothesized that previous hamstring injuries, reduced function scores, abnormalities on a clinical examination, high maximum sprint speed, poor hamstring strength, or low hamstring/quadriceps ratio can predict increased risk of new hamstring injuries.

Study Design: Cohort study; Level of evidence, 2.

Methods: A total of 508 players representing 31 amateur teams were tested during the 2004 preseason for potential risk factors for hamstring injury through a questionnaire on previous injury and function score (Hamstring Outcome Score [HaOS]), a clinical examination of the hamstring, and specific hamstring relevant tests. Generalized estimating equations were used in univariate analyses to identify candidate risk factors, and factors with a P value of <.10 were then examined in a multivariate model.

Results: During the soccer season, 76 hamstring injuries, affecting 65 legs (61 players), were registered. Univariate analyses revealed previous acute hamstring injury (yes/no) (odds ratio [OR], 2.62; 95% confidence interval [CI], 1.54-4.45), HaOS function score with all subscores except “Soreness” (OR for a 10-point difference in total score, 1.29; 95% CI, 1.08-1.54), age (OR, 1.25; 95% CI, 0.96-1.63), and player position (P = .09) as candidate predictors of high injury risk. In a multivariate analysis, the most important risk factor for injuries to the hamstring was previous acute hamstring injury (yes/no) (adjusted OR, 2.19; 95% CI, 1.19-4.03; P = .01).

Conclusion: In a multivariate analysis, previous acute hamstring injury was found to be a significant risk factor for new hamstring injuries. Previously injured players have more than twice as high a risk of sustaining a new hamstring injury.

Footwear Traction and Lower Extremity Joint Loading

Thursday, June 10th, 2010
  1. John W. Wannop*,
  2. Jay T. Worobets, PhD
  3. Darren J. Stefanyshyn, PhD

Am J Sports Med June 2010 38:1221-1228; doi:10.1177/0363546509359065

Abstract

Background: Traction is influenced by the sole architecture and playing surface, with increases in traction potentially leading to injury. The mechanism as to how or why increased traction could lead to injury remains unknown.

Purpose: This study was undertaken to determine how shoes of different sole designs and traction influence knee and ankle joint moments.

Study Design: Controlled laboratory study.

Methods: Traction testing was performed on 2 shoes of varying sole designs (tread vs smooth) using a robotic testing machine. All testing was conducted on a 60-cm × 90-cm piece of sample track surface. Kinematic and kinetic data were then collected on 13 recreational athletes performing running V-cuts in the 2 different shoe conditions. Five trials per condition were collected with reflective markers placed on the right shank and shoe of each participant. Kinematic and kinetic data were collected using an 8–high-speed camera system and force plate.

Results: The coefficient of translational traction and the peak moment of rotation were both significantly higher in the tread shoe compared with the smooth shoe (1.00 vs 0.87 and 23.87 N·m vs 16.12 N·m, respectively). The high-traction shoe had significantly higher peak ankle external rotation moments (89.58 N·m vs 80.17 N·m), peak knee external rotation moments (36.23 N·m vs 32.02 N·m), peak knee adduction moments (224.0 N·m vs 186.8 N·m), and knee adduction angular impulse (2.10 Nms vs 1.83 Nms) compared with the low-traction shoe.

Conclusion: Increased shoe traction significantly increased ankle and knee joint moments during a V-cut. Despite the significant difference in traction, no difference in performance was observed. These changes could have an effect on ankle and knee joint injury.

Clinical Relevance: Shoes with decreased traction could be used in sports to reduce the joint moments in the knee and ankle and potentially reduce injury without a loss in performance.

Shoe-Surface Friction Influences Movement Strategies During a Sidestep Cutting Task

Wednesday, March 31st, 2010

Abstract

Background Increasing the coefficient of friction of the shoe-surface interaction has been shown to lead to increased incidence of anterior cruciate ligament (ACL) injuries, but the causes for this increase are unknown. Previous studies indicate that specific biomechanical measures during landing are associated with an increased risk for ACL injury.

Hypothesis At foot contact during a sidestep cutting task, subjects use different movement strategies for shoe-surface conditions with a high coefficient of friction (COF) relative to a low friction condition. Specifically, the study tested for significant differences in knee kinematics, external knee moments, and the position of the center of mass for different COFs.

Study Design Controlled laboratory study.

Methods Twenty-two healthy subjects (11 male) were evaluated performing a 30° sidestep cutting task on a low friction surface (0.38) and a high friction surface (0.87) at a constant speed. An 8-camera markerless motion capture system combined with 2 force plates was used to measure full-body kinematics, kinetics, and center of mass.

Results At foot contact, subjects had a lower knee flexion angle (P = .01), lower external knee flexion moment (P < .001), higher external knee valgus moment (P < .001), and greater medial distance of the center of mass from the support limb (P < .001) on the high friction surface relative to the low friction surface.

Conclusion The high COF shoe-surface condition was associated with biomechanical conditions that can increase the risk of ACL injury. The higher incidence of ACL injury observed on high friction surfaces could be a result of these biomechanical changes. The differences in the biomechanical variables were the result of an anticipated stimulus due to different surface friction, with other conditions remaining constant.

Clinical Relevance The risk analysis of ACL injury should consider the biomechanical movement changes that occur for a shoe-surface condition with high friction.

Natural History of Concussion in Sport, Markers of Severity and Implications for Management

Wednesday, March 31st, 2010

Abstract

Background Evidence-based clinical data are required for safe return to play after concussion in sport.

Purpose The objective of this study was to describe the natural history of concussion in sport and identify clinical features associated with more severe concussive injury, using return-to-sport decisions as a surrogate measure of injury severity.

Study Design Cohort study (prognosis); Level of evidence, 3.

Methods Male elite senior, elite junior, and community-based Australian Rules football players had preseason baseline cognitive testing (Digit Symbol Substitution Test, Trail-Making Test–Part B, and CogSport computerized test battery). Players were recruited into the study after a concussive injury sustained while playing football. Concussed players were tested serially until all clinical features of their injury had resolved.

Results Of 1015 players, 88 concussions were observed in 78 players. Concussion-associated symptoms lasted an average of 48.6 hours (95% confidence interval, 39.5–57.7 hours) with delayed return to sport correlated with ≥4 symptoms, headache lasting ≥60 hours, or self-reported “fatigue/fogginess.” Cognitive deficits using the Digit Symbol Substitution Test and Trail-Making Test–part B recovered concomitantly with symptoms, but computerized test results recovered 2 to 3 days later and remained impaired in 35% of concussed players after symptom resolution.

Conclusion Delayed return to sport was associated with initially greater symptom load, prolonged headache, or subjective concentration deficits. Cognitive testing recovery varied, taking 2 to 3 days longer for computerized tests, suggesting greater sensitivity to impairment. Therefore, symptom assessment alone may be predictive of but may underestimate time to complete recovery, which may be better estimated with computerized cognitive testing.

Excessive Glenohumeral Horizontal Abduction as Occurs During the Late Cocking Phase of the Throwing Motion Can Be Critical for Internal Impingement

Sunday, February 28th, 2010

Background The objective of this study was to determine the effects of increased horizontal abduction with maximum external rotation, as occurs during the late cocking phase of throwing motion, on shoulder internal impingement.

Hypothesis An increase in glenohumeral horizontal abduction will cause overlap of the rotator cuff insertion with respect to the glenoid and increase pressure between the supraspinatus and infraspinatus tendon insertions on the greater tuberosity and the glenoid.

Study Design Controlled laboratory study.

Methods Eight cadaveric shoulders were tested with a custom shoulder testing system with the specimens in 60° of glenohumeral abduction and maximum external rotation. The amount of internal impingement was evaluated by assessing the location of the supraspinatus and infraspinatus articular insertions on the greater tuberosity relative to the glenoid using a MicroScribe 3DLX. Pressure in the posterior-superior quadrant of the glenoid was measured using Fuji prescale film. Data were obtained with the humerus in the scapular plane and 15°, 30°, and 45° of horizontal abduction from the scapular plane.

Results At 30° and 45° of horizontal abduction, the articular margin of the supraspinatus and infraspinatus tendons was anterior to the posterior edge of the glenoid and less than 2 mm from the glenoid rim in the lateral direction; the contact pressure was also greater than that found in the scapular plane and 15° of horizontal abduction.

Conclusion Horizontal abduction beyond the coronal plane increased the amount of overlap and contact pressure between the supraspinatus and infraspinatus tendons and glenoid.

Clinical Relevance Excessive glenohumeral horizontal abduction beyond the coronal plane may cause internal impingement, which may lead to rotator cuff tears and superior labral anterior to posterior (SLAP) lesions.

Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial Platelet-Rich Plasma Versus Corticosteroid Injection With a 1-Year Follow-up Joost C. Peerbooms, MD*, Jordi Sluimer, MD†, Daniël J. Bruijn, PhD* and Taco Gosens, PhD†‡

Sunday, February 28th, 2010

Abstract

Background Platelet-rich plasma (PRP) has shown to be a general stimulation for repair.

Purpose To determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis.

Study Design Randomized controlled trial; Level of evidence, 1.

Patients The trial was conducted in 2 teaching hospitals in the Netherlands. One hundred patients with chronic lateral epicondylitis were randomly assigned in the PRP group (n = 51) or the corticosteroid group (n = 49). A central computer system carried out randomization and allocation to the trial group. Patients were randomized to receive either a corticosteroid injection or an autologous platelet concentrate injection through a peppering technique. The primary analysis included visual analog scores and DASH Outcome Measure scores (DASH: Disabilities of the Arm, Shoulder, and Hand).

Results Successful treatment was defined as more than a 25% reduction in visual analog score or DASH score without a reintervention after 1 year. The results showed that, according to the visual analog scores, 24 of the 49 patients (49%) in the corticosteroid group and 37 of the 51 patients (73%) in the PRP group were successful, which was significantly different (P <.001). Furthermore, according to the DASH scores, 25 of the 49 patients (51%) in the corticosteroid group and 37 of the 51 patients (73%) in the PRP group were successful, which was also significantly different (P = .005). The corticosteroid group was better initially and then declined, whereas the PRP group progressively improved.

Conclusion Treatment of patients with chronic lateral epicondylitis with PRP reduces pain and significantly increases function, exceeding the effect of corticosteroid injection. Future decisions for application of the PRP for lateral epicondylitis should be confirmed by further follow-up from this trial and should take into account possible costs and harms as well as benefits.

Excessive Glenohumeral Horizontal Abduction as Occurs During the Late Cocking Phase of the Throwing Motion Can Be Critical for Internal Impingement

Sunday, February 28th, 2010

Abstract

Background The objective of this study was to determine the effects of increased horizontal abduction with maximum external rotation, as occurs during the late cocking phase of throwing motion, on shoulder internal impingement.

Hypothesis An increase in glenohumeral horizontal abduction will cause overlap of the rotator cuff insertion with respect to the glenoid and increase pressure between the supraspinatus and infraspinatus tendon insertions on the greater tuberosity and the glenoid.

Study Design Controlled laboratory study.

Methods Eight cadaveric shoulders were tested with a custom shoulder testing system with the specimens in 60° of glenohumeral abduction and maximum external rotation. The amount of internal impingement was evaluated by assessing the location of the supraspinatus and infraspinatus articular insertions on the greater tuberosity relative to the glenoid using a MicroScribe 3DLX. Pressure in the posterior-superior quadrant of the glenoid was measured using Fuji prescale film. Data were obtained with the humerus in the scapular plane and 15°, 30°, and 45° of horizontal abduction from the scapular plane.

Results At 30° and 45° of horizontal abduction, the articular margin of the supraspinatus and infraspinatus tendons was anterior to the posterior edge of the glenoid and less than 2 mm from the glenoid rim in the lateral direction; the contact pressure was also greater than that found in the scapular plane and 15° of horizontal abduction.

Conclusion Horizontal abduction beyond the coronal plane increased the amount of overlap and contact pressure between the supraspinatus and infraspinatus tendons and glenoid.

Clinical Relevance Excessive glenohumeral horizontal abduction beyond the coronal plane may cause internal impingement, which may lead to rotator cuff tears and superior labral anterior to posterior (SLAP) lesions.

  1. Teruhisa Mihata, MD, PhD*,
  2. Michelle H. McGarry, MS*,
  3. Mitsuo Kinoshita, MD, PhD and
  4. Thay Q. Lee, PhD*

Glenohumeral, Scapular, and Thoracic Angles at Maximum Shoulder External Rotation in Throwing

Sunday, February 28th, 2010

Abstract

Background Because a majority of throwing injuries occur near the maximum external rotation (MER) of the throwing shoulder, sports medicine practitioners and researchers have paid special attention to the shoulder kinematics at the MER in throwing. However, little is known about the individual kinematics of the glenohumeral, scapulothoracic, and thoracic joints at the MER.

Purpose To demonstrate the glenohumeral, scapulothoracic, and thoracic joint movements and their contribution to the MER in throwing for baseball players.

Study Design Descriptive laboratory study.

Methods We collected throwing motion data for 20 collegiate baseball players by using 3 high-speed cameras and established 3-dimensional coordinates of each landmark with a direct linear translation method. We then obtained the MER of the shoulder complex, the external rotation angle of the glenohumeral joint, the posterior tipping angle of the scapula, and the thoracic extension angles at the MER in throwing.

Results The mean (± standard deviation) value of the MER was 144.2° ± 11.0°. The mean (± standard deviation) values of the glenohumeral external rotation, the scapular posterior tipping, and the thoracic extension angles at the MER were 105.7° ± 15.5°, 23.5° ± 13.9°, and 8.9° ± 7.3°, respectively.

Conclusion Our results indicate that not only the glenohumeral joint movement but also the scapular and thoracic movements make major contributions to the MER angle.

Clinical Relevance To better understand the pathomechanics of the shoulder complex in throwing, we need to take into account the individual contributions of the glenohumeral, scapulothoracic, and thoracic extension movements to the MER.

  1. Koji Miyashita, PhD, PT*,
  2. Hirokazu Kobayashi, MS, PT,
  3. Sentaro Koshida, PhD, AT§ and
  4. Yukio Urabe, PhD, PT||

Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial

Monday, February 8th, 2010

Abstract

Background Platelet-rich plasma (PRP) has shown to be a general stimulation for repair.

Purpose To determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis.

Study Design Randomized controlled trial; Level of evidence, 1.

Patients The trial was conducted in 2 teaching hospitals in the Netherlands. One hundred patients with chronic lateral epicondylitis were randomly assigned in the PRP group (n = 51) or the corticosteroid group (n = 49). A central computer system carried out randomization and allocation to the trial group. Patients were randomized to receive either a corticosteroid injection or an autologous platelet concentrate injection through a peppering technique. The primary analysis included visual analog scores and DASH Outcome Measure scores (DASH: Disabilities of the Arm, Shoulder, and Hand).

Results Successful treatment was defined as more than a 25% reduction in visual analog score or DASH score without a reintervention after 1 year. The results showed that, according to the visual analog scores, 24 of the 49 patients (49%) in the corticosteroid group and 37 of the 51 patients (73%) in the PRP group were successful, which was significantly different (P <.001). Furthermore, according to the DASH scores, 25 of the 49 patients (51%) in the corticosteroid group and 37 of the 51 patients (73%) in the PRP group were successful, which was also significantly different (P = .005). The corticosteroid group was better initially and then declined, whereas the PRP group progressively improved.

Conclusion Treatment of patients with chronic lateral epicondylitis with PRP reduces pain and significantly increases function, exceeding the effect of corticosteroid injection. Future decisions for application of the PRP for lateral epicondylitis should be confirmed by further follow-up from this trial and should take into account possible costs and harms as well as benefits.